It's very hard to find an interesting science fiction game with some of the preferences that I have any expectations that I always want to have them in the game. Some of them ended up being disappointed but a few games still amazed me.
Sci-fi on PC:
Another World (Eric Chahi; Delphine Software, 1991)
Star Control 2 (Paul Reiche III / Fred Ford; Toys for Bob, 1992)
Doom (id Software, 1993)
The Dig (Lucasarts, 1995)
Fallout 1 (Interplay Productions, 1997)
Half-Life 1 (Valve, 1998)
Freespace 2 (Volition, 1999)
System Shock 2 (Irrational Games / Looking Glass Studios, 1999)
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Evolva (Computer Artworks, 2000)*
Project Eden (Core Design, 2001)*
Beyond Good and Evil (Ubisoft, 2003)
Freelancer (Digital Anvil, 2003)
Halo Combat Evolved (Bungie, 2003)
Half-Life 2 (Valve, 2004)
Mass Effect 1 (PC version; Bioware, 2008)
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Mass Effect 2 (Bioware, 2010)
Portal 2 (Valve, 2011)
Deus Ex Human Revolution (Eidos Montreal, 2011)
Borderlands 2 (Gearbox Software, 2012)
Mass Effect 3 (Bioware, 2012)
Metro Last Light Redux (4A Games, 2014)
Fallout 4 (Bethesda Softworks, 2015)
Hyper Light Drifter (Heart Machine, 2016)
XCOM 2 (Firaxis Games, 2016)
The Way (Puzzling Dream, 2016)
Games that I haven't decided to play yet
X COM UFO Defense (Julian Gollop / MicroProse, 1994)*
Fade to Black (Delphine Software International, 1995)*
Outwars (SingleTrac, 1998)*
--
Evolva (Computer Artworks, 2000)*
Project Eden (Core Design, 2001)*
--
XCOM Enemy Unknown (Firaxis Games, 2012)*
Ring Runner Flight of the Sages (Triple-B-Titles, 2013)*
Xeodrifter (Renegade Kid, 2014)*
Subnautica (Unknown Worlds, 2018)*
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Games I wasn't into
Anachronox (Ion Storm, 2001)
The only big problem is the combat system is boring to me in a RPG game.
The first part of the plot was okay to me, but then the middle part of the game wasn't my thing.